Ibicuruzwa
Amazi-Soluble Quercetin yo gutanga intungamubiri zisumba izindi
Quercetin Amazi-Yashubije: Kongera Bioavailability no Gukora Ubupayiniya Ibihe bishya byubuzima
Quercetin, ifumbire ya flavonoide iboneka cyane mu biribwa bitandukanye bishingiye ku bimera nk'ibitunguru, pome, n'imbuto, bimaze igihe kinini byibandwaho mu bushakashatsi bwa siyansi no mu biganiro by’ubuzima, bitewe na antioxydants ikomeye, irwanya inflammatory, n’ibindi bikorwa binyuranye by’ibinyabuzima. Nyamara, kuba amazi yabyo adasanzwe arashobora kubangamira cyane iyinjizwa ryayo nogukoresha mumubiri wumuntu, bityo bikagabanya kumenya neza ubuzima bwayo. Mu myaka yashize, hamwe niterambere rikomeje gutera imbere mubumenyi nubuhanga, hagaragaye quercetin ikemura amazi, ikemura ibibazo byo gukemura ibibazo bya quercetin gakondo kandi ikerekana uburyo bwagutse bwo gukoresha nibyiza bidasanzwe.
Guhindura Bioavailability: Kunesha Inzitizi za Absorption
Quercetin gakondo, bitewe nubushobozi buke bwamazi, irwanira gushonga mumyanya yigifu nyuma yubuyobozi bwo munwa, bikavamo umuvuduko muke cyane. Ubushakashatsi bwerekana ko igipimo cyacyo cyo kwinjiza amara kiri hafi 2%. Ibinyuranye, quercetin ikemura amazi ikoresha tekinoroji igezweho, nka tekinoroji ya nanomicelle hamwe na tekinoroji ya cyclodextrin, kugirango itezimbere cyane mumazi. Kurugero, Laboratoire ya Dryland Nshya Yubushakashatsi bwubushakashatsi bwamajyepfo ya Subtropical Crops Institute, Ubushinwa bwubumenyi bwubumenyi bwubuhinzi bwubushinwa, bwateguye neza nanomicelles yuzuye quercetin ikoresheje uburyo bwo guhuza imiti. Ubu bushya bwazamuye cyane amazi ya quercetin, amazi, gufotora, no gufata neza selile. Kubera iyo mpamvu, quercetin irashobora gushonga neza mumazi ya gastrointestinal, ikongera aho ihurira na selile zo mu mara kandi ikazamura cyane imikorere yayo mumubiri wumuntu. Ubushakashatsi bujyanye n’ubushakashatsi bwerekana ko bioavailable ya quercetin ikabura amazi ishobora kwiyongera inshuro nyinshi cyangwa ndetse ugereranije na quercetine gakondo, bigatuma umubiri wakira neza kandi ugakoresha ibice bigize quercetine kandi bikingura byimazeyo ingaruka ziteza imbere ubuzima.
Porogaramu zitandukanye zubuzima
1. Amaraso ya Glucose
Quercetin y'amazi ashonga itanga ibyiringiro bishya kubantu bahangayikishijwe n'ubuzima bwa glucose. Ubushakashatsi bwakozwe n’ikigo cy’ubushakashatsi cy’imbuto cya Zhengzhou, Ishuri ry’Ubumenyi bw’Ubuhinzi mu Bushinwa, bwerekanye ko quercetin, ifatanije n’izindi mbuto flavonoide, ishobora guhuza ibikorwa bya α-glucosidase. α-Glucosidase igira uruhare runini muri hydrolysis ya karubone, kandi guhagarika ibikorwa byayo birashobora guhagarika neza igogorwa no kwinjiza karubone, bityo bigafasha kugenzura urugero rwa glucose yamaraso nyuma yinyuma. Hamwe no gukomera kwinshi no kwinjizwa neza, quercetin ikabura amazi irashobora kugira uruhare runini mukubuza α-glucosidase, gutanga inkunga ikomeye mugutezimbere ibicuruzwa bikora bigamije kugenzura glucose yamaraso nyuma yinyuma. Ibi bifite ingaruka zikomeye ku micungire yubuzima bwa buri munsi y’abarwayi ba diyabete cyangwa abafite umuvuduko w’amaraso glucose.
2. Kurinda ubuzima bwumwijima
Quercetin ikemura amazi nayo irabagirana mukubungabunga ubuzima bwumwijima. Ubushakashatsi bwakozwe nitsinda rya Porofeseri Peng Cheng wo muri kaminuza ya Chengdu y’ubuvuzi gakondo bw’Abashinwa bwerekanye ko quercetin ishobora guhindura umwijima w’ibinure by’inzoga binyuze mu guhuza ibisasu bya kirimbuzi bya TFEB kugira ngo yishyure autofagy idahagije. Kwiyongera kwinshi kwa quercetin kumazi-eruble ituma igera mwumwijima byihuse kandi neza, igashimangira imikorere ya autofagic ya selile yumwijima, igatera metabolisme yamavuta mumwijima, ikanorohereza kurandura ibintu byangiza. Ibi bifasha kwirinda no kunoza indwara zinyuranye zumwijima, nkumwijima wamavuta nindwara yumwijima inzoga, mukugabanya ibyangijwe ninzoga nibindi bintu byangiza umwijima.
3. Kuzamura imisatsi
Gutakaza umusatsi ni impungenge rusange kubantu benshi, kandi quercetin ikemura amazi itanga igisubizo gishya kuri iki kibazo. Ubushakashatsi bwakozwe n’itsinda rya Porofeseri Qu Jing bo mu kigo cya Zoology, Ishuri Rikuru ry’Ubumenyi bw’Ubushinwa, bwerekanye ko quercetin ishobora guteza imbere kongera imisatsi binyuze mu gukoresha inzira ya HIF-1 mu ngirabuzimafatizo za endoteliyale y’imisatsi y’ibidukikije. Quercetin y'amazi ashobora gushonga irashobora kwinjira mumaraso kandi ikagera ahantu h'imisatsi, bikagira ingaruka nziza kubitegeko byangiza ibidukikije. Itera gutandukanya no gukwirakwira kwingirangingo z'umusatsi, bityo bigatuma umusatsi ukura. Niba umusatsi watewe no guhangayika, kutaringaniza imisemburo, cyangwa izindi mpamvu, quercetin ikemura amazi itanga amasezerano nkumuti wizewe kandi mwiza.
4. Kongera imbaraga za sisitemu
Quercetin ubwayo ifite ibikorwa bimwe na bimwe byo gukingira indwara, nko guteza imbere ibikorwa bya macrophage no gusohora ibintu bifitanye isano n’umubiri. Kuza kwa quercetin kumazi-gushonga byongera inyungu. Amazi meza cyane yo gukemura neza atuma habaho gukwirakwizwa mu mubiri, bigatuma ukora neza cyane mubice bitandukanye bigize sisitemu yumubiri. Itezimbere ibikorwa bya selile yumubiri kandi iteza imbere gusohora ibintu byubudahangarwa nkibibyimba bya nekrosis-α na interferon-γ, bifasha umubiri kwirinda neza indwara ziterwa na virusi kandi bikongera cyane ubudahangarwa muri rusange. Ibi biha abantu imbaraga zo guhangana cyane mugihe bahuye nibibazo byubuzima nka virusi yibicurane na virusi.
Umwirondoro wumutekano hamwe nigihe kizaza
Gutegura amazi ya eregitoronike ya quercetin yiganjemo gukoresha uburyo bwa tekinike bwizewe kandi bwangiza ibidukikije, nkikoranabuhanga rya nanomicelle twavuze haruguru. Ubu buryo butezimbere amazi ya quercetin atabanje kwinjiza imiti yangiza, kurinda umutekano wibicuruzwa. Byongeye kandi, bitewe na bioavailability yongerewe imbaraga, hasabwa urugero rwo hasi rwa quercetin kugirango ugere ku nyungu zimwe zubuzima, bikagabanya cyane ingaruka ziterwa ningaruka mbi.
Hamwe nogukomeza gushakisha ubushakashatsi no guhanga udushya twikoranabuhanga, quercetin ikemura amazi yiteguye kwerekana imbaraga nyinshi zikoreshwa mubiribwa bikora, inyongera zimirire, amavuta yo kwisiga, ninganda zimiti. Mu rwego rwibiryo bikora, birashobora kwinjizwa mubinyobwa bitandukanye no kurya, bigaha abaguzi kurinda ubuzima bwiza. Mu nganda zo kwisiga, gukoresha imisatsi igarura imisatsi hamwe na antioxydeant, ibicuruzwa bifite imikorere nko kurwanya umusatsi no gusaza birwanya uruhu birashobora gutezwa imbere. Mu rwego rwa farumasi, hari amasezerano menshi yo kurushaho gushakisha uburyo akoreshwa mu kuvura indwara zidakira no gufasha mu kuvura imiti, gufungura inzira nshya y’ubushakashatsi bw’ubuvuzi n’ubuzima.
Reba
1.Ikigo cy’ubushakashatsi cy’ibihingwa byo mu majyepfo, Ishuri ry’Ubushinwa ry’ubumenyi bw’ubuhinzi. (nd). Iterambere Rishya muri Nano Kuramba-Kurekura Ibikoresho Bitwara Ibiyobyabwenge. Yakuwe kuri http://m.toutiao.com/group/7164215338974839308/?upstream_biz=doubao
2.Peng, C., n'abandi. (nd). Quercetin igabanya Ethanol - iterwa na hepatike steatose mungirangingo za L02 muguhindura TFEB kugirango yishyure autofagy idahagije. UBUSHAKASHATSI BWA PHYTOTHERAPY (Icyiciro cya kabiri mu Ishuri Rikuru ry'Ubushinwa). Yakuwe mububiko bwamasomo
3.Qu, J., n'abandi. (nd). Ingaragu - Ingirabuzimafatizo yerekana uruhare rukomeye rwa Quercetin mugutezimbere imisatsi. Poroteyine & Akagari. Yakuwe kuri https://m.ikinyamakuru.cn/amakuruAmakuru_yimbere_21318679
4.Jin, Z., n'abandi. (2024). Co - enapsulation ya quercetin na resveratrol: Kugereranya mubice bitandukanye bya zein - carboxymethyl selulose nanoparticles. Ikinyamakuru mpuzamahanga cya Biologiya Macromolecules, 263, Ingingo ya 127439. Https://doi.org/10.1016/j.ijbiomac.2024.127439
5.Ikigo cyubushakashatsi bwimbuto cya Zhengzhou, Ishuri Rikuru ryUbumenyi bwUbuhinzi. (2024). Flavonoide mu mbuto igenga Glucose Yamaraso. Yakuwe kuri http://www.xinhuanet.com/ubuhanga/20241105/c730eb7ee20a4e0ab8d2ec96570044ca/c.html
