Isoquercetin - Ibinyabuzima bikora byinshi

Byakozwe na Xi'an Umukororombya Bio-Tech Co, Ltd, Umuhanga wambere wa Phytochemical Innovator

1. Intangiriro kuri Isoquercetin

Isoquercetin (CAS No 482-35-9), glycoside ya flavonol ikomoka kuri quercetin, ni ibintu bisanzwe biboneka mu bwoko bwa polifenolike biboneka mu bimera bitandukanye, birimo igitunguru, pome, pome, n’ibiti bivura imiti nka Ginkgo biloba na Hippophae rhamnoides. Nkibintu byingenzi byibinyabuzima bikora, byitabiriwe cyane mubikorwa bya farumasi, intungamubiri, ibiryo, no kwisiga kubera antioxydants ikomeye, anti-inflammatory, hamwe nubuvuzi. Iyi nyandiko itanga incamake yuzuye ya isoquercetin, harimo imiterere yimiti, ibipimo byubuziranenge, porogaramu zitandukanye, hamwe nubuhanga bwikoranabuhanga bwa [Izina ryisosiyete yawe] mugutanga ibisubizo bya isoquercetin.

2. Ibiranga shingiro bya Isoquercetin
2.1 Imiterere yimiti nibyiza

Form Inzira ya molekulari:C₂₁H₂₀O₁₁
Weight Ibiro bya molekulari:464.38 g / mol
Structure Imiterere yimiti:Flavonol aglycone (quercetin) ihujwe na molekile ya glucose ikoresheje umugozi wa glycoside (3-O-glucoside).
Aper Kugaragara ku mubiri:Ifu yumuhondo ya kristaline ifite uburyohe bukaze.
Ububasha:Kubura amazi make; gushonga muri Ethanol, methanol, na DMSO.
● Guhagarara:Yumva urumuri n'ubushyuhe; gihamye mugihe cyububiko bugenzurwa (2-8 ° C).

2.2 Inkomoko Kamere

Isoquercetin irahari cyane muri:

Ibimera:Ibinyomoro (Fagopyrum esculentum), igitunguru (Allium cepa), pome (Malus domestica), n'imbuto (urugero, ubururu, cranberries).
Bs Ibimera bivura:Ginkgo biloba (amababi), Hypericum perforatum (Wort ya Mutagatifu Yohani), na Sophora japonica (igiti cyitwa pagoda cy'Ubuyapani).
● Ibiryo:Icyayi kibisi, vino itukura, nubwoko bumwe na bumwe bwubuki.

2.3 Bioactivite hamwe nuburyo bukoreshwa

Activity Igikorwa cya Antioxydeant:Scavenges radicals yubusa (urugero, hydroxyl, superoxide) kandi ikabuza guhagarika umutima binyuze mukugenzura ibimenyetso bya Nrf2.
Kurwanya Kurwanya:Kurwanya cytokine pro-inflammatory (TNF-α, IL-6) kandi ikabuza gukora NF-κB inzira.
Indwara yumutima:Itezimbere imikorere ya endoteliyale, igabanya umuvuduko wamaraso, kandi ikabuza gukusanya platine.
Anticancer:Itera apoptose mu ngirangingo za kanseri (urugero, amabere, ibihaha, ibara) kandi ikabuza angiogenez.
● Neuroprotective:Irinda indwara zifata ubwonko (urugero, Alzheimer's, Parkinson) mugabanya kwangiza okiside no gutwika.

3. Ubwiza bwibicuruzwa: Premium-Grade Isoquercetin na Xi'an Umukororombya Bio-Tech CO., Ltd
3.1 Ibipimo byera no gushiraho

● Isuku:≥98% (HPLC isuzuma, USP / EP / BP yujuje).
Ibyuma biremereye:≤10 ppm (ICP-MS yageragejwe).
Safety Umutekano wa Microbiologiya:Yubahiriza USP <61> na <62> (isahani yuzuye ≤1000 CFU / g, umusemburo / ifu ≤100 CFU / g, nta E. coli cyangwa Salmonella).
Ibisigisigi bya Solvent:≤0.5% (Ethanol, methanol; GC-MS yapimwe).

3.2 Uburyo bwo kubyaza umusaruro

Umukororombya Xi'an Bio-Tech Co, Ltd ikoresha uburyo bwo kuvoma no kweza ibidukikije:

1.Isoko ry'ibikoresho bito:Ibimera byo mu rwego rwo hejuru biva mu bikoresho byo mu gasozi.
2.Gukuramo:Gukuramo Ultrasound (UAE) hamwe n'ibishishwa byo mu rwego rwo kurya (Ethanol / amazi).
3.Kwezwa:Inkingi ya chromatografiya (silika gel / ODS) hamwe na HPLC yitegura kwigunga cyane.
4.Formulation:Gusasira-gukama cyangwa gukonjesha-gukama kugirango ubyare ifu nziza cyangwa granules ifite ubunini buke (10-100 μ m).

3.3 Sisitemu yo kugenzura ubuziranenge (QC)

Laboratoire zigezweho:Bifite ibikoresho bya HPLC, LC-MS, NMR, na GC-MS kugirango bipimishe bikomeye.
● Batch Traceability:Inyandiko zuzuye kuva mubikoresho kugeza kubicuruzwa byanyuma (ISO 22000: 2018 byujuje).
Icyemezo:Impamyabumenyi ya Kosher, Halal, na FSSC22000.

4. Gushyira mu bikorwa Isoquercetin
4.1 Inganda zimiti

Development Guteza imbere ibiyobyabwenge:
Agents Abakozi ba Anticancer:Byakozwe muburyo bwo kuvura (urugero, hamwe na cisplatine) kugirango byongere cytotoxicity no kugabanya ingaruka mbi.
Drugs Ibiyobyabwenge byumutima:Ikoreshwa muri antivypertensive na anticoagulant (urugero, coenzyme Q10 + ibinini bya isoquercetin).
Ibiyobyabwenge bya Neuroprotective:Yinjijwe muri prototypes yo kuvura Alzheimer (urugero, donepezil + capsules isoquercetin).

4.2 Intungamubiri nimirire

Benefits Inyungu zubuzima:
Support Inkunga yubudahangarwa, kurwanya gusaza, no kugenzura metabolike (urugero, gucunga amaraso glucose).
Health Ubuzima bufatanije (kugabanya osteoarthritis inflammation).

Products Ibicuruzwa byo ku isoko:
● Capsules (200-500 mg isoquercetin / kumunsi).
Ibinyobwa bikora (urugero, icyayi kibisi cya isoquercetin).

4.3 Inganda zibiribwa n'ibinyobwa

Ings Ibikoresho bikora:
Kubungabunga ibidukikije (byongerera igihe cyo kubaho binyuze mu bikorwa bya mikorobe).
Fort Gukomeza imirire (intungamubiri za antioxydeant mumitobe, ibiryo).

4.4 Amavuta yo kwisiga no kwita ku muntu ku giti cye

Health Ubuzima bwuruhu:
Protection Kurinda Antioxydants kwirinda kwangirika kwa UV.
Kurwanya gusaza (kuzamura kolagen synthesis, kugabanya iminkanyari).
Kurwanya inflammatory uruhu rworoshye (urugero, eczema, rosacea).

● Imiterere:
● Serumu, amavuta, na masike (0.5-2% isoquercetin).

4.5 Ubuvuzi bw'amatungo

Health Ubuzima bw'inyamaswa:
Kurwanya inflammatory inyamanswa (urugero, osteoarthritis mu mbwa).
Support Inkunga yubudahangarwa mu matungo (igabanya kwangirika kwatewe na okiside).

5. Umukororombya Xi'an Bio-Tech Co, Ltd - Umufatanyabikorwa Wizewe muri Phytochemical Innovation
5.1 Incamake yisosiyete

Yashinzwe mu mwaka wa 2010, Xi'an Rainbow Bio-Tech Co., Ltd ni umuyobozi ku isi mu bushakashatsi, iterambere, n’umusaruro w’ibinyabuzima bishingiye ku bimera. Hamwe na 20.000 m² yemewe na GMP hamwe nitsinda ryabahanga 150+, turihariye muri:

Gukuramo no kweza flavonoide, alkaloide, na polifenol.
Manufacturing Gukora amasezerano (CMO) kubakiriya ba farumasi nintungamubiri.
Form Guhitamo nyirubwite (urugero, nanoencapsulated isoquercetin kugirango bioavailable ibeho).

5.2 Ubushobozi bwa R&D

Ubufatanye:Ubufatanye na kaminuza zikomeye (urugero, kaminuza isanzwe ya Shaanxi) n'ibigo by'ubushakashatsi.
Patent:12+ patenti yo gukuramo isoquercetin, kuyikora, no kuyikoresha.

5.3 Umusaruro mwiza

Ubushobozi:Toni 10 metric / umwaka wa isoquercetin (95-99% ubuziranenge).
● Kuramba:Umusaruro wa zeru ukoresheje gufunga-gufunga solvent recycling.
Ach Kugera ku isi hose:Yakoreye abakiriya 200+ mubihugu 30+ (urugero, USA, EU, Ubuyapani, Ositaraliya).

5.4 Serivisi zabakiriya

Support Inkunga ya tekiniki:Gutegura dossier yihariye (urugero, DMF, CEP).
Compl Kubahiriza amabwiriza:Inkunga yuzuye kubitangwa na FDA, EFSA, na TGA.
Options Amahitamo yo gupakira:Gupakira ibicuruzwa (imifuka ya aluminiyumu, ingoma ya HDPE) hamwe nubushuhe / kurinda urumuri.

6. Umwanzuro: Isoquercetin - Igisubizo gisanzwe kubibazo bigezweho

Isoquercetin ya bioactivite itandukanye ibishyira nkibikoresho byibanze mu buvuzi, imirire, no kwita ku muntu ku giti cye. Xi'an Rainbow Bio-Tech Co, Ltd yiyemeje ubuziranenge, guhanga udushya, no kuramba byemeza ko ibicuruzwa byacu bya isoquercetin byujuje ubuziranenge ku isi. Haba iterambere ryibiyobyabwenge, inyongeramusaruro, cyangwa kwisiga, ibisubizo byacu biha imbaraga inganda gukoresha ubushobozi bwa kamere mubuzima bwiza.

Ihuze amaboko na Xi'an Rainbow Bio-Tech Co, Ltd - aho siyanse ihura na kamere.