Shakisha nmn: fungura urugendo rushya rwubuzima nubuzima

Mu rugendo rwo gukurikirana ubuzima no gutinza abasaza, ubushakashatsi bwa siyansi buri gihe butuzanira ibyiringiro bishya nibishoboka. Mu myaka yashize, NMN (Nikonikanide Monnotatide), ibintu bikomokaho bya binyabuzima, byagiye binjira mu jisho rusange kandi bitondera cyane. Niki mubyukuri? Kandi ni ukubera iki yakuyeho urugendo nk'urwo mu buzima? Reka dushuke mu mayobera ya NMN hamwe.

NMN ni iki?  

NMN, aribyo, nicoinamide monnonucletide, ni molekile isanzwe ibaho mubuzima bwose. Mu mubiri w'umuntu, NMN ni intangiriro nyamukuru kuri synthesi ya Coenzyme I (NAD +). Coenzyme I (NAD +) yitabira ibintu byinshi byingenzi byingenzi muri kazoli no kurwana uruhare runini mugukomeza imikorere nubuzima busanzwe bwa selile. Nkabantu baje, urwego rwa NAD + mumubiri wabantu garaga garaga garaga garagabanuka, bikaba biterwa hafi nimpinduka nyinshi za physiologiya zijyanye no gusaza nibibaho no guteza imbere indwara. Guhura na NMN birashobora kongera ibintu neza muri NAD + mumubiri, bityo gutanga inkunga ihagije kubikorwa bisanzwe bya selile no gufasha kubungabunga imiterere yumubiri.

Ihame rya NMN

Uburyo bwo gukora bwa NMN bushingiye cyane cyane ku buturwe bwa nad +. Iyo tugereranije NMN, byinjiye vuba numubiri kandi duhinduka muri NAD + munsi yumurimo wuruhererekane. Nka Coenzyme kuri enzymes nyinshi zuzuye, Nad + yitabira ibikorwa byingenzi bya physiologiologique muri selile, nka metabolism, gusana, no gusana, no kugenzura imvugo ya gene. Kubijyanye n'ingufu metabolism, Nad + agira uruhare mubikorwa byuhushya, ifasha Mitochondria guhindura intungamubiri muri ATP, ingufu za molekile zirashobora gukoresha. Urwego ruhagije nad + rufite uruhare mu kuzamura imikorere n'imikorere ya Mitochondria, bitanga imbaraga nyinshi kuri selire kandi bidushoboza kugira imbaraga n'ubuzima bwiza. Mubice bya ADN, Nad + ni insimburana ryingenzi kuri Parp (ADP ya ADP - Umuryango wa Ribosse) umuryango. Iyo selile zangirika na ultraviolet imirasire, ibitero bya okilidative, nibindi, endzzles ikora kandi igakoresha nad + kugirango ukoreshe na obp +, hanyuma ushake proteine ​​zijyanye no gusana ADN wangiritse. Kubungabunga urwego rwo hejuru rwa NAD + rushobora kongera ibikorwa bya endzymes, wihutisha gahunda yo gusana ya ADN, gabanyamurwanyirize hamwe no kwangirika kwa MONNA no kwangiza seliki, kandi mpinduke gukumira ibintu bibaye - indwara zijyanye. Byongeye kandi, Nad + yarimo agira uruhare mu mategeko ya Sirtduins umuryango wa Proteine. Sirtduins Proteins Gukina Inshingano Zingenzi Mu Kubakira Akazu, Amabwiriza ya Metabolly, Ibisubizo bya Injizari, nibindi Mugukangura NMN kugirango wongere na Nad

Imikorere ya NMN

1: gutinda senescence

Inzira yo gusaza iherekejwe no kugabanuka gahoro gahoro imikorere yinzego zamafaranga na sisitemu mumubiri. NMR yatinze gusaza murwego rwa selile binyuze munzira nyinshi nko kongera imbaraga zabasa naga na mitochondrial, kuzamura ubushobozi bwa mitochondrial, no gukoresha ubushobozi bwo gusana bwa ADN, no gukoresha sittuins proteines. Ubushakashatsi bwerekana ko inyongera na NMN rishobora kunoza cyane imikorere yinyamaswa zigeragezwa, nko kuzamura imbaraga zumutsi, kuzamura imikorere yo kwihangana, no kuzamura imikorere yubwenge, kandi bigatera imbere imikorere yubwenge, bigatuma bigaragara kandi bitwara muri leta kikiri nto. Kubantu, kwiyongera kwigihe kirekire na NMN nabyo biteganijwe ko gutinda guhita bishaje, gabanya isura yimiterere nubuzima rusange, kandi bizamura urwego rwubuzima rusange, kandi rukateze imbere urwego rwubuzima, rukagutera imbaraga nubuzima bwiza nubuzima.

2: kuzamura ubudahangarwa

NMN ifite ingaruka nziza kumurongo wa sisitemu yumubiri. Ku ruhande rumwe, irashobora guteza imbere ubushuhe no gutandukanya ingirabuzimafatizo zangiza, kuzamura ibikorwa bya selile zangiza, no kunoza ubushobozi bwumubiri. Ku rundi ruhande, NMN ifasha gukora umurimo usanzwe wa mitochondria mu tugari k'umubiri, gutanga inkunga ihagije ku bikorwa bya selile. Muguhutira NMn, dushobora kongera ubudahangarwa bwacu, kugabanya ibyago byo kurwara, kandi tukareba ingorane z'ibidukikije byo hanze.

3:Kuzamura imikorere ya metabolike

Gudashoboka kwa Metabolic nintandaro yindwara nyinshi zidakira, nkubumuga, diyabete, indwara z'umutima imizitisi, nibindi. NMN irashobora kunoza imikorere ya metabolike igenga inzira ya metabolic muri selile. Ubushakashatsi bwabonye ko inyongera na NMN ishobora kuzamura insuline, iteze imbere uptake kandi igakoresha glucose, kandi ifashe gukomeza isukari ya maraso. Muri icyo gihe, NMN irashobora kandi kuzamura metabolism yabyibushye, igabanya kwirundanya ibinure mumubiri, kandi ifite uruhare rwiza mugukumira no kunoza umubyibuho ukabije. Byongeye kandi, NMN ifite ingaruka zo gukingira kuri sisitemu yumutima. Irashobora kugabanya urwego rwa Lipid Lipid, kunoza imikorere ya Endoteliyali ya Endoteliya, kandi igabanye ibyago byindwara zumubiri. Kubahangayikishijwe nubuzima bwa metabolike, NMN ntagushidikanya ku buryo bwuzuyemo imirire hamwe nagaciro kashoboka.

4:Kunoza imikorere yubwenge

Hamwe no gukura kw'imyaka, imikorere yubwonko igenda igabanuka buhoro buhoro, kwibuka kugabanuka, indwara zubwenge nibindi bibazo bigenda bihangayikishwa nabasaza. NMN yerekanye ingaruka zizere mugutezimbere imikorere yubwenge.

Twandikire: Judy Guo

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