Ur Urolixin A.
Urolithin A (mu magambo ahinnye yiswe UA) ni uruganda rusanzwe rwa polifenol ikorwa na microbiota yo mu mara metabolism ya ellagitannins. Ellagitannine iboneka cyane mu biribwa nk'amakomamanga, strawberry, raspberries, walnuts, na vino itukura. Iyo abantu barya ibyo biryo, ellagitannine ihinduka urolithine A nabantu ba mikorobe yihariye mu mara.
Properties Ibintu shingiro bya urolithine A.
Izina ry'icyongereza: Urolithin A.
Numero ya CAS: 1143-70-0
Imiterere ya molekile. : C₁₃H₈O₄
Uburemere bwa molekile: 228.2
Kugaragara: Ifu yumuhondo cyangwa yoroheje yumuhondo ukomeye
● Bioactivite na efficacy ya urolixin A.
1:Ingaruka zo gusaza
Kongera imikorere ya mitochondrial: urolithin A irashobora gukangura mitofagy, ifasha kuvanaho mitochondriya yangiritse, guteza imbere kubyara mitochondriya nshya, ikora, kugirango igumane ingufu za metabolisme yingirabuzimafatizo no gutinda gusaza. Kongera ubuzima bwimikorere ya selile no kongera ubuzima bwimikorere ya selile, urolixine A ifasha kwagura ubuzima bwingirabuzimafatizo.
2:Ingaruka ya Neuroprotective
Mugabanye neuroinflammation: Urolitine A irashobora kurenga inzitizi yubwonko bwamaraso, kugabanya amyloide beta (Aβ) na tau protein ibikomere, no gutera indwara ya mitochondrial autophagy, bityo bikazamura ibimenyetso byindwara zifata ubwonko nkindwara ya Alzheimer nindwara ya Parkinson.
3:Kurinda imitsi
Ongera imbaraga z'imitsi no kwihangana: Urolixin A irashobora guteza imbere ubuzima bwimitsi, kongera imbaraga zimitsi no kwihangana, kandi ikagira uruhare runini muguhuza imitsi indwara ziterwa na dystrofi yimitsi. Guteza imbere imitsi: Mugutegeka uburyo nkimikorere ya mitochondrial mumitsi yimitsi, urolixin A ifasha abasaza cyangwa abantu bafite ibibazo byimikorere bitewe nindwara gukora imyitozo isabwa no guteza imbere imitsi.
4:Ingaruka zo kurwanya inflammatory
Kubuza ibintu bitera umuriro: urolithine A irashobora kubuza kubyara no kurekura ibintu bitera nka IL-6 na TNF-α, kandi bikagabanya ibisubizo byumuriro.Gutegeka inzira zerekana ibimenyetso byerekana umuriro: Muguhagarika imikorere ya NF-κB, MAPK nizindi nzira zerekana ibimenyetso, urolitine A irongera kugabanya igisubizo cyumuriro.
5:antioxyde
Scavenging radicals yubusa: Urolixin A ifite ubushobozi bwo gukuraho byimazeyo radicals yubusa no kugabanya kwangirika kwingutu ya okiside ku ngirabuzimafatizo. Kongera imbaraga zo kwirinda antioxydeant: Urolixin A irashobora kongera ubushobozi bwa anti -xydeans anti -xydeans selile ikoresheje inzira ya antioxydeant ya Nrf2 na glutathione ya glutathione.
6:Ingaruka zo kurwanya
Kubuza ikwirakwizwa ry'uturemangingo twibibyimba: urolixine A irashobora kubuza ikwirakwizwa, gutera na metastasis ya kanseri ya prostate, kanseri yumura nizindi selile yibibyimba. Kwinjiza kanseri yibibyimba apoptose: Mugukoresha inzira zerekana ibimenyetso bya apoptose, urolixin A irashobora gutera kanseri yibibyimba apoptose, bityo bikabuza gukura kwikibyimba.
7:Kunoza indwara ziterwa na metabolike
Kugenga isukari mu maraso na lipide yamaraso: urolithine A irashobora kugenga inzira ya metabolike yumubiri kandi ikagira uruhare runini mukuzamura isukari yamaraso hamwe na lipide yamaraso.
8:Kunoza indwara zimpyiko
Kugabanya imvune zimpyiko: Urolixin A irashobora kugabanya imvune zimpyiko ukoresheje mitochondrial autophagy ya selile yimpyiko, kugabanya kwirundanya kwa kolagen, kugabanya ikwirakwizwa rya fibrocyte cyangwa kugabanya imitsi ya fibre kugirango bidindiza iterambere rya fibrosis.
Icyizere cyo gusaba urolithin A.
1:Ubushakashatsi bwibiyobyabwenge niterambere
Urolixin A ni intego izwi cyane mu kurwanya gusaza, neuroprotective, kurwanya ibibyimba biterwa n’ibikorwa by’ibinyabuzima bitandukanye. Kugeza ubu, ibigo byinshi by’ubushakashatsi n’ibigo byatangiye kwiga ku iterambere ry’ibiyobyabwenge bya urolixin A, bizeye guteza imbere imiti ikora neza kandi itekanye.
2:Ubushakashatsi bwo kwisiga niterambere
Ingaruka za antioxydeant na anti-inflammatory ya urolixin A ituma igira amahirwe menshi yo gukoreshwa mubijyanye no kwisiga.Mu kongeramo urolixine A, kwisiga birashobora kongera ingaruka zo kurwanya gusaza no kunoza imiterere yuruhu.
3:Ubushakashatsi bwibiryo niterambere
Urolixin A ifite agaciro gakoreshwa mubiribwa kubera imirimo yayo itandukanye yibinyabuzima.Mu kongeramo ibiryo bikungahaye kuri ellagitannin cyangwa urolithine A inyongera, ibiryo birashobora kongera inyungu zubuzima kandi bigahaza abaguzi kubiryo byiza.
Twandikire: Judy Guo
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Igihe cyo kohereza: Werurwe-27-2025