Kumenyekanisha PQQ: Imbaraga Zirenze Zitera Ubwenge numubiri

Kumenyekanisha PQQ: Imbaraga Zirenze Zitera Ubwenge numubiri

Pyrroloquinoline quinone, yitwa PQQ, ni itsinda rishya rya prostate rifite imikorere isa na vitamine. Iraboneka cyane muri prokaryote, ibimera n’inyamabere, nka soya yasembuwe cyangwa natto, urusenda rwatsi, imbuto za kiwi, Parsley, icyayi, papaya, epinari, seleri, amata yonsa, nibindi.

Mu myaka yashize, PQQ yabaye imwe mu ntungamubiri "inyenyeri" zashimishije abantu benshi. Muri 2022 na 2023, igihugu cyanjye cyemeje PQQ yakozwe na synthesis na fermentation nkibikoresho bishya byibiribwa.

Imikorere yibinyabuzima ya PQQ yibanze cyane mubice bibiri. Icya mbere, irashobora gushyigikira imikurire niterambere rya mitochondriya kandi igatera imikurire yihuse yingirabuzimafatizo zabantu; icya kabiri, ifite antioxydants nziza, ishobora gufasha gukuraho radicals yubusa no kugabanya kwangirika kwingirabuzimafatizo. Iyi mikorere yombi ituma igira uruhare runini mubuzima bwubwonko, ubuzima bwumutima nimiyoboro, ubuzima bwa metabolike nibindi bintu. Kuberako umubiri wumuntu udashobora guhuza PQQ wenyine, ugomba kongerwaho binyuze mubyokurya.

01. Uruhare rwa PQQ mugutezimbere ubumenyi ruhabwa agaciro cyane

Muri Gashyantare 2023, abashakashatsi b'Abayapani basohoye inyandiko y'ubushakashatsi bise "Umunyu wa Pyrroloquinoline quinone disodium utezimbere imikorere y'ubwonko haba ku bakiri bato ndetse n'abakuru" mu kinyamakuru "Food & Function", bamenyekanisha ubumenyi bwa PQQ ku rubyiruko ndetse n'abantu bakuze mu Buyapani. Kunoza ibisubizo byubushakashatsi.

Ubu bushakashatsi bwari impumyi zibiri zihumeka zageragejwe zirimo abagabo 62 b'Abayapani bafite ubuzima bwiza bafite hagati yimyaka 20-65, hamwe na Mini-Mental State Scale amanota ≥ 24, bakomeje ubuzima bwabo bwambere mugihe cyo kwiga. Imbaga y'abagore. Amasomo yubushakashatsi yagabanyijwemo itsinda ryitabiriwe nitsinda rishinzwe kugenzura ibibanza, kandi byahawe umunwa PQQ (20 mg / d) cyangwa capsules ya buri munsi ibyumweru 12. Sisitemu yo kwipimisha kumurongo yakozwe nisosiyete yakoreshejwe mukumenya ibyumweru 0/8/12. Ikizamini cyubwenge gisuzuma imikorere yubwonko 15 ikurikira.

Ibisubizo byerekanaga ko ugereranije nitsinda rishinzwe kugenzura umwanya, nyuma yibyumweru 12 byo gufata PQQ, kwibuka hamwe hamwe nibuka mumagambo amanota yibice byose hamwe nitsinda ryabasaza ryiyongereye; nyuma yibyumweru 8 byo gufata PQQ, itsinda ryitsinda ryubwenge bworoshye, gutunganya umuvuduko hamwe n amanota yihuta yiyongera.

02 PQQ ntishobora gusa kunoza imikorere yubwonko bwabasaza gusa, ahubwo inatezimbere ubwonko bwurubyiruko!

Muri Werurwe 2023, ikinyamakuru kizwi cyane ku rwego mpuzamahanga ku biribwa & Imikorere cyasohoye urupapuro rw’ubushakashatsi rwiswe "Umunyu wa Pyrroloquinoline quinone disodium utezimbere imikorere yubwonko haba mu bakuze ndetse n'abakuru". Ubu bushakashatsi bwakoze iperereza ku ngaruka za PQQ ku mikorere y’ubwenge y’abantu bakuru bafite imyaka 20-65, yongerera umubare w’inyigisho za PQQ kuva ku bageze mu za bukuru kugeza ku rubyiruko. Ubushakashatsi bwerekanye ko PQQ ishobora kunoza imikorere yubwenge bwabantu bingeri zose.

Ubushakashatsi bwerekanye ko PQQ, nkibiryo bikora, ishobora kunoza imikorere yubwonko mumyaka iyo ari yo yose, kandi biteganijwe ko yagura ikoreshwa rya PQQ nkibiryo bikora kuva mubasaza kugeza kubantu bingeri zose.

03 PQQ ikora nka activate y "inganda zingufu zingirabuzimafatizo" kugirango igarure ubuzima bwabo

Muri Gicurasi 2023, Cell Death Dis yasohoye inyandiko y’ubushakashatsi yise Umubyibuho ukabije wangiza mitophagy iterwa na cardiolipine hamwe na mikorobe yo kuvura mitochondrial ubushobozi bwo kwimura ingirabuzimafatizo ya Mesenchymal. Ubu bushakashatsi bwavumbuye PQQ isuzuma niba ubushobozi bw’abaterankunga ba mitochondial intercellular selile yabantu bafite umubyibuho ukabije (abantu bafite ibibazo bya metabolike) hamwe ningaruka zo kuvura ingirabuzimafatizo ya Mesenchymal stem selile (MSCs) zangiritse, kandi niba imiti igabanya ubukana bwa mitochondial ishobora kubihindura. Guhindura bigarura ubuzima bwa mitochondial kugirango bigabanye mitofagy yangiritse.
Ubu bushakashatsi butanga ubumenyi bwambere bwa molekuline yunvikana ya mitofagy yangiritse mumyanya myibarukiro ikomoka kumubyibuho ukabije kandi yerekana ko ubuzima bwa mitochondial bushobora kugarurwa binyuze mumabwiriza ya PQQ kugirango bagabanye mitofagy yangiritse.

04 PQQ irashobora kunoza imikorere ya metabolike yabantu

Muri Gicurasi 2023, hasubiwemo ingingo isubiramo yiswe "Pyrroloquinoline-quinone kugira ngo igabanye ibinure no kuzamura umubyibuho ukabije" mu kinyamakuru Front Mol Biosci, kivuga mu ncamake ubushakashatsi 5 bw’inyamaswa n’ubushakashatsi 2 bw’akagari.
Ibisubizo byerekana ko PQQ ishobora kugabanya ibinure byumubiri, cyane cyane ibinure byijimye hamwe numwijima, bityo bikarinda umubyibuho ukabije. Duhereye ku isesengura ry'amahame, PQQ ibuza cyane lipogenezi kandi igabanya ikwirakwizwa ry'amavuta mu kunoza imikorere ya mito-iyambere no guteza imbere metabolism.

05 PQQ irashobora kwirinda osteoporose iterwa no gusaza bisanzwe

Muri Nzeri 2023, Akagari gasaza kasohoye inyandiko y’ubushakashatsi yiswe "Quinone ya Pyrroloquinoline igabanya gusaza kavukire - ifitanye isano na osteoporose ikoresheje igitabo MCM3 - Keap1 - Nrf2 axis - gukemura ibibazo by’ingutu no kugenzura Fbn1" kuri interineti. Ubushakashatsi, binyuze mu bushakashatsi bwakozwe ku mbeba, bwerekanye ko inyongeramusaruro ya PQQ ishobora kwirinda osteoporose iterwa no gusaza bisanzwe. Uburyo bwibanze bwubushobozi bwa antioxydeant ya PQQ butanga ishingiro ryikigereranyo cyo gukoresha PQQ nkinyongera yimirire yo kwirinda ostéoporose iterwa nimyaka.
Ubu bushakashatsi bugaragaza uruhare nuburyo bushya bwa PQQ mukurinda no kuvura ostéoporose ya senile, kandi byerekana ko PQQ ishobora gukoreshwa nkinyongera yimirire yizewe kandi ikingira indwara yo gukumira no kuvura ostéoporose. Muri icyo gihe kandi, byagaragaye ko PQQ ikora ikimenyetso cya MCM3-Keap1-Nrf2 muri osteoblasts, igahindura mu buryo bwandikirwa imvugo ya gen antioxydeant na gen Fbn1, ikabuza guhagarika umutima hamwe na osteoclast amagufwa, kandi ikarinda gusaza amagufwa ya osteoblast. uruhare mukubaho osteoporose yimibonano mpuzabitsina.

06 Kuzuza PQQ birashobora kurinda uturemangingo twa ganglion kandi bigatera ubuzima bwiza bwamaso!

Muri Nzeri 2023, ikinyamakuru Acta Neuropathol Commun cyasohoye ubushakashatsi bw’inzobere n’inzobere mu bijyanye n’amaso n’intiti zo mu bitaro by’amaso by’ikigo cya Karolinska kiri i Stockholm, muri Suwede, ishuri ry’ubuvuzi rizwi cyane ry’i Burayi, ndetse n’ibitaro bya Royal Victoria Eye n’amatwi muri Ositaraliya, n’ishami ry’ibinyabuzima rya kaminuza ya Pisa mu Butaliyani. Yiswe "Pyrroloquinoline quinone itwara synthesis ya ATP muri vitro no muri vivo kandi itanga retinal ganglion selile neuroprotection." Ubushakashatsi bwerekanye ko PQQ igira ingaruka zo kurinda ingirabuzimafatizo (RGC) kandi ifite imbaraga nyinshi nk'umukozi mushya wa neuroprotective agent mu kurwanya selile apoptose.
Ibyavuye mu bushakashatsi bishyigikira uruhare rwa PQQ nkibintu bishya byerekana amashusho ya neuroprotective agent bishobora kunoza imbaraga za selile retinal ganglion mugihe bigabanya ingaruka zishobora guterwa. Muri icyo gihe, abashakashatsi bemeza ko kuzuza PQQ ari uburyo bwiza bwo kubungabunga ubuzima bw'amaso.

07 Kuzuza PQQ birashobora kugenga flora yo munda, kunoza imikorere ya tiroyide, no kugabanya kwangirika kwa tiroyide.

Ukuboza 2023, itsinda ry’ubushakashatsi ryaturutse mu bitaro by’abantu icumi bya Shanghai by’ishuri ry’ubuvuzi rya kaminuza ya Tongji ryasohoye inkuru yise "Uruhare rushoboka rwa Pyrroloquinoline Quinone yo kugenzura imikorere ya Thyroid na Gut Microbiota igizwe n’indwara z’imva mu mbeba" mu kinyamakuru Pol J Microbiol Muri iki kiganiro, abashakashatsi bakoresheje urugero rw’imbeba kugira ngo berekane intangangore P no kunoza imikorere ya tiroyide.
Ubushakashatsi bwerekanye ingaruka zinyongera za PQQ ku mbeba za GD hamwe n’ibimera byo mu nda:

01 Nyuma yinyongera ya PQQ, serumu TSHR na T4 yimbeba za GD zaragabanutse, kandi ubunini bwa glande ya tiroyide bwaragabanutse cyane.

02 PQQ igabanya gucana no guhagarika umutima, kandi igabanya kwangirika kw amara mato.

03 PQQ ifite ingaruka zikomeye mugusubiza ibintu bitandukanye hamwe na microbiota.

04 Ugereranije nitsinda rya GD, kuvura PQQ birashobora kugabanya ubwinshi bwa Lactobacilli mu mbeba (ubu ni uburyo bwo kuvura intego ya GD).

Muri make, inyongera ya PQQ irashobora kugenga imikorere ya tiroyide, kugabanya kwangirika kwa tiroyide, no kugabanya gucana no guhagarika umutima, bityo bikagabanya kwangirika kw amara mato. Kandi PQQ irashobora kandi kugarura ubudasa bwibimera byo munda.

Usibye ubushakashatsi bwavuzwe haruguru bugaragaza uruhare runini nubushobozi butagira imipaka bwa PQQ nkinyongera yimirire yo kuzamura ubuzima bwabantu, ubushakashatsi bwibanze nabwo bwakomeje kwemeza imikorere ikomeye ya PQQ.

08 PQQ irashobora kunoza hypertension yimpyisi

Mu Kwakira 2022, inyandiko y’ubushakashatsi yiswe "Pyrroloquinoline quinone (PQQ) itezimbere umuvuduko ukabije w’imitsi igenga imikorere ya mitochondrial na metabolic" yasohotse mu kinyamakuru Pulmonary Pharmacology & Therapeutics, igamije kumenya uruhare rwa PQQ mu kuzamura umuvuduko ukabije w'amaraso.
Ibisubizo byerekana ko PQQ ishobora kugabanya imitekerereze idasanzwe ya mitochondial na metabolike idasanzwe mu mitsi iva mu mitsi yoroheje kandi ikadindiza iterambere rya hypertension yimpyisi ku mbeba; kubwibyo, PQQ irashobora gukoreshwa nkibishobora kuvura imiti igabanya umuvuduko ukabije w'amaraso.

09 PQQ irashobora gutinza gusaza kwakagari no kongera ubuzima!

Muri Mutarama 2020, inyandiko y’ubushakashatsi yitwa Pyrroloquinoline quinone itinda gutwika iterwa na TNF-α binyuze kuri p16 / p21 na Jagged1 yerekana inzira yasohotse muri Clin Exp Pharmacol Physiol yagenzuye mu buryo butaziguye ingaruka zo kurwanya gusaza kwa PQQ mu ngirabuzimafatizo z'abantu. , ibisubizo byerekana ko PQQ itinda gusaza kwabantu kandi ishobora kongera igihe.

Abashakashatsi basanze PQQ ishobora kudindiza gusaza kwabantu, kandi bakagenzura neza uyu mwanzuro binyuze mubisubizo byerekana ibisubizo byibinyabuzima byinshi nka p21, p16, na Jagged1. Hasabwe ko PQQ ishobora kuzamura ubuzima rusange bwabaturage no kongera igihe cyo kubaho.

10 PQQ irashobora gukumira gusaza kwintanga ngore no gukomeza uburumbuke

Muri Werurwe 2022, inyandiko y’ubushakashatsi yiswe "PQQ Dietary Supplement Yirinda Alkylating Agent-Indwara ya Ovarian Dysfunction mu mbeba" yasohotse mu kinyamakuru Front Endocrinol, igamije kwiga niba inyongeramusaruro ya PQQ irinda indwara ya alkylating agent iterwa no gukora nabi intanga ngore. Ingaruka.
Ibisubizo byerekanye ko inyongera ya PQQ yongereye uburemere nubunini bwintanga ngore, igarura igice cya estrous cyangiritse, kandi ikarinda gutakaza imisemburo yimbeba zavuwe na alkylating agent. Byongeye kandi, inyongera ya PQQ yongereye cyane igipimo cyo gutwita nubunini bwimyanda kuri buri kubyara mu mbeba zivuwe na alkylating. Ibisubizo byerekana ubushobozi bwo gutabarana kwa PQQ muri alkylating agent-iterwa na ovarian idakora neza.

Umwanzuro
Mubyukuri, nkinyongera yimirire mishya, PQQ yamenyekanye kubera ingaruka nziza ku mirire nubuzima. Kubera imikorere yayo ikomeye, umutekano muke hamwe no guhagarara neza, ifite iterambere ryagutse mubijyanye nibiribwa bikora.
Mu myaka yashize, hamwe n’ubumenyi bwimbitse, PQQ yageze ku cyemezo cyuzuye cy’ingirakamaro kandi ikoreshwa cyane nk'inyongera y'ibiryo cyangwa ibiryo muri Amerika, Uburayi ndetse no mu bindi bihugu n'uturere. Mu gihe abakiriya b’imbere mu gihugu bakomeje kwiyongera, bemeza ko PQQ, nk'ibiribwa bishya, izarema isi nshya ku isoko ry’imbere mu gihugu.

Reba:

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