Kumenyekanisha Pqq: Ingufu zanyuma zongera ibitekerezo numubiri

Kumenyekanisha Pqq: Ingufu zanyuma zongera ibitekerezo numubiri

PyrrouloquinaLine Quinone, ivugwa nka Pqq, ni itsinda rishya rya prostate ifite imirimo isa na vitamine. Biboneka cyane muri Prokaryary, ibimera n'inyamabere, nka soya isenyutse cyangwa ibinyamiseke, urubingo rw'icyatsi, peteroli, icyayi, eleri, amata yonsa, nibindi.

Mu myaka yashize, Pqq yabaye imwe mu intungamubiri za "inyenyeri" zagiye zitondera cyane. Muri 2022 na 2023, igihugu cyanjye cyemeje PQQ Yakozwe na Synthesis na fermentation nk'ibiribwa bishya.

Imikorere y'ibinyabuzima ya PQQ ihabwa cyane muri bibiri. Ubwa mbere, irashobora gushyigikira iterambere niterambere rya Mitochondria no gukangura iterambere ryihuse ryabantu; Icya kabiri, ifite ibintu byiza bya Antioxyditent, bishobora gufasha gukuraho imirasire yubusa no kugabanya ibyangiritse. Iyi mirimo yombi igira uruhare rukomeye mubuzima bwubwonko, ubuzima bwumubiri, ubuzima bwa metabolike nibindi bintu. Kuberako umubiri wumuntu udashobora guhagarika Pqq wenyine, ugomba kwiyongera ukoresheje imirire.

01.PQQ's uruhare mugutezimbere kumenya agaciro cyane

Muri Gashyantare 2023, abashakashatsi b'Abayapani basohoye impapuro z'ubushakashatsi "Umunyu wa PyrrouloquinaLine Quinone watezimbere imikorere y'ubwonko ndetse n'abakuru" mu binyamakuru. Kunoza ibisubizo byubushakashatsi.

Ubu bushakashatsi bwari ubunini bubiri bugizwe n'ikigeragezo kigenzurwa kigenzurwa kirimo imyaka 62 n'Amatsinda ya Leta ya mini-mu mutwe, ifite amanota ya Leta ya mini-mu mutwe, yakomeje imibereho yabo y'umwimerere mu gihe cyo kwiga. Imbaga y'abagore. Ibintu byubushakashatsi byagabanijwemo itsinda ryo gutabara hamwe nitsinda rigenzura ryumwanya, kandi ryatangaga umunwa Pqq (20 mg / d) cyangwa papdules ya buri munsi ibyumweru 12. Sisitemu yo kwipimisha kumurongo yateguwe nisosiyete yakoreshejwe muguranga mubyumweru 0/8/12. Ikizamini cyo kumenya gisuzuma imikorere yubwonko 15 ikurikira.

Ibisubizo byerekanye ko ugereranije nitsinda rigenzura ryaho, nyuma yibyumweru 12 bya PQQ bifata, ububiko bwibintu hamwe nuburyo bwinshi bwo kwibuka mumatsinda yose hamwe nitsinda rigeze mu za bukuru ryiyongera; Nyuma yibyumweru 8 bya PQQ ifata, itsinda ryurugendo ruto rwiza, ritunganya umuvuduko no gucikamo amanota yihuta.

02 Pqq ntishobora kunoza imikorere yubwonko gusa yabasaza, ariko nanone kunoza ubutumwa bwurubyiruko!

Muri Werurwe 2023, imikorere izwi cyane y'ibiryo & imikorere yatangajwe impapuro z'ubushakashatsi yitwa "Umunyu wa PyrrouloquinaLine Quinone Quinone utezimbere imikorere y'ubwonko muri bombi bato n'abakuru" bato n'abakuru ". Ubu bushakashatsi bwakoze ubushakashatsi ku ngaruka za PQQ ku mikorere yo kumenya abantu bakuru bafite imyaka 20-65, kwagura abaturage biga PQQ yo ku busaza ku bageze mu za bukuru. Ubushakashatsi bwagaragaje ko PQQ ishobora kunoza imikorere yubuvuzi yabantu bafite imyaka yose.

Ubushakashatsi bwabonye ko Pqq, nk'ibiryo bikora, bishobora guteza imbere imikorere y'ubwonko ku myaka iyo ari yo yose, kandi biteganijwe ko izagura ikoreshwa rya PQQ nk'ibiryo bikora biva mu bageze mu zabukuru ku bageze mu za bukuru.

03 Pqq ikora nkumukoresha w'inganda za "selile selile" kugirango ugarure ubuzima bwabo

Muri Gicurasi 2023, urupfu rwakarengane rwatangaje impapuro zubushakashatsi rwiswe umubyibuho ukabije utabangamiye mitophagy nubushobozi bwo kwimura imitsi mitophondrial. Ubu bushakashatsi bwavumbuye pqq mugusuzuma niba ubushobozi bwa Mitochondrial Intera ya Mitochondrial (abantu bafite ibibazo bya metabolike) hamwe nibibazo bya MitoCHymal (MSCS) byangiritse, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba ubuvuzi bwa Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba imiti ya Mitochondrial, kandi niba ubuvuzi bwa Mitochondrial Modulation yagaruye ubuzima bwa Mitochondrial kuri mitape ya Mitiphagy.
Ubu bushakashatsi butanga uburyo bwa mbere bwuzuye bwo gusobanukirwa Mithiféed Mitophagy mu tugari twa Mesenchymal, tugaragaza ko ubuzima bwa Mitochondrial bushobora gusubirwamo binyuze mu mabwiriza ya PQQ kugira ngo atandukane na mitiphagy.

04 Pqq irashobora kunoza imikorere ya muntu metabolike

Muri Gicurasi 2023, hasohotse ingingo yo gusuzuma "QyroloquinOne-Qorroure yo kugabanya ibinure ndetse n'inkuru z'ikinyamakuru Mol Biosci, ivuga muri make amasomo 5 yinyamaswa.
Ibisubizo byerekana ko Pqq ishobora kugabanya ibinure byumubiri, cyane cyane kwigitarure kandi byumwijima kandi birinda umubyibuho ukabije. Kuva isesengura ry'ihame, Pqq cyane kubuza lipogenesi kandi bigabanya urugwiro mu kunoza imikorere mitochondrial no guteza imbere metabolism.

05 pqq irashobora kubuza osteopororos iterwa no gusaza bisanzwe

Muri Nzeri 2023, gusangira selile byasohoye impapuro zubushakashatsi "PyRroloquinoline Quireopose ijyanye na ONEL ikoresheje umurongo wa MCM3-Umwanya wa Ax3-NRF2 Ubushakashatsi, binyuze mubushakashatsi ku rubibe, basanze iyo smotary PQQIbikoresho bya PQQ birashobora kubuza osteopororos biterwa no gusaza. Uburyo bwibanze bwa PQQ bukomeye bwa Antioxydant itanga igeragezwa rya PQQUM ryakoreshejwe nkinyongera yimirire kugirango birinde osteooporome ijyanye nubuzima.
Ubu bushakashatsi bugaragaza uruhare rukomeye hamwe na pqq muburyo bwo gukumira no kuvura osteoporose ya salle, kandi igaragaza ko Pqq ishobora gukoreshwa nkinyongera nziza kandi nziza kugirango wirinde kandi ivure Osteoporose ya Sele. Muri icyo gihe, byagaragaye ko PQQ ikora ibimenyetso bya MCM3-KRF2 i Osteblasts, bibuza imigabane ya Okidiodidant hamwe na osteoclast ya osteoclast, bityo bikazamura amagufwa ya osteoclast, bityo bigashimangira gusaza. uruhare mu gihe cya Osteoporose yimibonano mpuzabitsina.

06 Kwiyongera Pqq birashobora kurinda selile zagutse kandi zinoza ubuzima bwijisho!

Muri Nzeri 2023, Ikinyamakuru Acta Neuropathol Kor yasohoye inzoga n'intiti z'ubuvuzi zifatika muri Storitska Yiswe "Ikibazo cya Pyrrouloquinoline gitwara synthesis muri vitro no muri Vitwi no gutanga imiyoboro ya ganglion ya regill." Ubushakashatsi bwagaragaje ko Pqq ifite ingaruka zo kurinda ingirabuzimafatizo za reginal (RGC) kandi zifite amahirwe menshi nkabakozi bashya ba NeuroPillivective mu kurwanya selire ya ganglion apoptose ya reginal.
Ibyagaragaye bishyigikira uruhare rushobora kuba pqq nkumukozi wa Negorwa NeuroPirizotective Agent ishobora kunoza kwihangana kwa selile zagutse mugihe cyo kugabanya ingaruka zingaruka zishoboka. Muri icyo gihe, abashakashatsi bemeza ko kuzuza Pqq ari uburyo bwiza bwo gukomeza ubuzima bw'amaso.

07 Kuzuza Pqq birashobora kugena ibimera byimbaho, kuzamura imikorere ya tiroyide, no kugabanya ibyangiritse bya tiroyide.

Ukuboza 2023, itsinda ry'abashakashatsi baturutse mu bitaro bya cumi na kimwe mu bitaro bya kaminuza ya Tongji byo mu Buvuzi byatangajwe n'indwara ya TyRoquiota no kugena icyitegererezo cya TyRodiota kugira ngo igenzure imikorere ya Tyroide mu miterere y'imbeba. kugabanya ibyangiritse mu nda, no kunoza imikorere ya tiroyide.
Ubushakashatsi bwabonye ingaruka zinyongera ya PQQ kuri GD imbeba za GD hamwe na flora zabo zuzuye:

01 Nyuma yo korezo rya PQQ, Serum TSHR na T4 imbeba za GD zagabanutse, kandi ubunini bwa Glande ya tiroyide bwaragabanutse cyane.

02 Pqq igabanya imitekerereze nubushake, kandi igabanya ibyangiritse bito.

03 Pqq ifite ingaruka zikomeye zo kugarura ibintu bitandukanye nibigize microbiota.

04 Ugereranije nitsinda rya GD, kuvura pqq birashobora kugabanya ubwinshi bwa lactobacilli muburyo (iyi ni uburyo bwo kuvura intego ya GD).

Muri make, kwiyongera kwa PQQ birashobora kugenga imikorere ya tiroyide, kugabanya ibyangiritse bya tiroyide, no kugabanya imihangayiko nimihangayiko, bityo bikagabanya ibintu bito byangiritse. Na Pqq birashobora kandi kugarura ubudasa bwinyamanswa.

Usibye Inyigisho zavuzwe haruguru zerekana uruhare runini nubushobozi butagira imipaka bwa PQQ nkinyongera yimirire kugirango anoze ubuzima bwabantu, ubushakashatsi bwambere kandi bwakomeje kandi kwemeza imikorere ikomeye ya PQQ.

08 Pqq irashobora guteza imbere hypertension

Mu Kwakira 2022, impapuro z'ubushakashatsi zitiriwe "PQRROUONE QUONONE (PQQ) bitezimbere imikorere y'igifungo n'imiterere ya MitoChorlogy & TheRapeutics, bigamije gushakisha uruhare rwa PQQ mu kunoza hypertension.
Ibisubizo byerekana ko Pqq ishobora kugabanya mitochondrial bidasanzwe na metabooc idasanzwe mu mashanyarazi yoroheje imitsi yoroheje kandi ikatinda iterambere ryimiterere yimbeba; Kubwibyo, Pqq irashobora gukoreshwa nkumukozi wa Orapeutic kugirango atezimbere hypertension.

09 Pqq irashobora gutinza selile ishaje kandi ikagura ubuzima!

Muri Mutarama 2020, impapuro z'ubushakashatsi yitwa Pyrroloquinoline Qyrroutoline Quinone yatinze gucika intege zatanzwe muri Clin Physiol Physiol yamenyekanye muri PQI. , Ibisubizo byerekana ko Pqq itinda kubyara selile kandi irashobora kwagura ubuzima bwiza.

Abashakashatsi basanze Pqq ishobora gutinza gusaza kwa selile, kandi akomeza agenzura umwanzuro unyuze mu mvugo y'ibinyabuzima benshi nka P21, P16, na Jagged1. Birasabwa ko PQQ ishobora kuzamura ubuzima rusange bwabaturage no kwagura ubuzima.

10 Pqq irashobora gukumira intanga ngore kandi zigumane uburumbuke

Muri Werurwe 2022, impapuro zubushakashatsi "PQQ Imvururu zibuza alkylating alkylating agent-yashyizwe mubikorwa byimbeba Endocrinol, yasohotse mu kinyamakuru Endocrinol, agamije kwiga niba imbaraga za Intent-zitera intanga ngoroho. ingaruka.
Ibisubizo byerekanaga ko inzika ya PQQ yongereye uburemere nubunini bwimibare, ikangirika igice cyinzoka yangiritse, kandi ikabuza igihombo cyangiritse, kandi ibuza gutakaza igihome cyangiritse, kandi ibuza igihombo cyangiritse, kandi kibuza gutakaza igihome cyangiritse, kandi kibuza igihombo cya follicles mu mbondo zivuwe hamwe nabakozi ba alkylating. Byongeye kandi, inyongera ya PQQ yiyongereye cyane igipimo cyo gutwita no mubunini bwamanuka kuri buri giciro muri alkylating agent-imbeba. Ibisubizo byerekana ubushobozi bwo guhagarika PQQ muri Alkylating Cant-yatewe na Ovarian.

Umwanzuro
Mubyukuri, nkinyongera nshya yimirire, Pqq yamenyekanye kubwimirire yayo yimirire nubuzima. Kubera imirimo yayo ikomeye, umutekano mwinshi hamwe nuburemere bwiza, ifite ibyifuzo byagutse murwego rwibiryo bikora.
Mu myaka yashize, hamwe no kwimbitse ubumenyi, Pqq yageze ku cyemezo cyuzuye kandi ikoreshwa cyane nk'inyongera yimirire cyangwa ibiryo muri Amerika, Uburayi no mu bindi bihugu. Nkuko abaguzi bo murugo bakomeje kwiyongera, bizera ko Pqq, nkibiryo bishya, bizashinga isi nshya, izarema isi nshya mu isoko ryimbere mu gihugu.

INGINGO:

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